How to Enter a Study

  • To find out about our current studies, call: 646-774-8000 and speak to one of our staff. After a brief telephone screening, we may ask you to make an appointment for a visit to determine whether your are eligible for one of our studies

  • You can also visit for details about this study, Desvenlafaxine vs. Placebo in Chronic Depression

Questions about participating in our studies:

What is a clinical trial?
One way to identify new treatments and to develop further insight into the causes and symptoms of mood disorders is through clinical trials. A clinical trial is a medical research study which often focuses on the effectiveness and safety of a specific type of treatment. At the Mood Disorders Research Program (MDRP), we only offer clinical trials of medications for which safety information is already known, and we focus primarily on the effectiveness of the treatment. In some studies, some of the people participating take a placebo (an inactive pill) instead of the study drug. In other studies, everyone takes the study drug. You will be told which type of study you might participate in. Everyone eventually will receive active medication.

What can I expect during my first visit?
The first visit involves a comprehensive interview with a psychiatrist and a psychologist. During this interview, you will be asked questions about your mood, sleep patterns, energy level, and appetite. You will also be asked to give a blood and urine sample to determine whether there are medical causes of your depression or other problems which may complicate your treatment. In addition, it may also be necessary to perform a physical examination and/or an ECG so that we can accurately diagnose your mood disorder and any other conditions you may have. Upon completing the evaluation, your doctor will discuss your diagnosis with you, along with recommendations for treatment.

What does treatment involve?
If you are eligible for one of our clinical trials, you will come to our office at Roosevelt Hospital for regularly scheduled visits. Routine visits with your doctor allow us to closely monitor your treatment and provide optimum clinical care. At these visits, you will meet with your doctor and discuss your progress and the effectiveness of the treatment. The clinical trials vary in length, as does the frequency of visits.

How much does treatment cost?
The MDRP is supported by private funding, mostly from pharmaceutical companies, and as a result, all evaluations are provided at no cost to you. If you are eligible for one of our clinical trials, study drugs are also provided free of charge.

What treatments are available?
The MDRP focuses on treating depression using medication. The specific drugs that are available depends on the nature of your depression and what clinical trials are currently being conducted. In addition, new clinical trials are being developed all the time. Our colleagues in the Depression Evaluation Service or other programs at Columbia Psychiatry and the NY State Psychiatric Institute may also have ongoing psychotherapy studies. For more specific information about the available treatments, call 646-774-8000  or visit our website:

Who comes to the MDRP?
The MDRP specializes in treating adults who suffer from various types of mood disorders, including depression and manic-depression. Our patients are diverse, ranging in age from 18 to 75. Some come to us after trying a number of other treatments, either medication or psychotherapy, and others come to us seeking treatment for the first time.


and would like information about participating in our studies, please contact us at: 646-774-8000

Text Box: Affiliated with the Department of Psychiatry, Columbia University College of Physicians & Surgeons and the New York State Psychiatric Institute



The New York State Psychiatric Institute

Columbia University Department of Psychiatry 
Specializing in Treatment and Research

of Chronic Depression

   Mood Disorders Research Program/

      Depression Evaluation Service

   1775 Broadway , Suite #1403   (57th St)

   New York, NY 10019

   Tel. 646-774-8000